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Unparalleled proactive care. Optimizing the SCS experience. Website: neuro.biotronik.com

Simon Little, MBBS, PhD

Associate Professor of Neurology
University of California San Francisco
San Francisco, California, United States

Dr Little is a neurologist-scientist, highly motivated by the prospect of understanding the fundamental circuitry of neurological diseases with the long-term research goal to advance personalization of medication and neuromodulation therapies in neurological disorders (e.g. Parkinson’s disease, dystonia and tremor) and non-motor symptoms (inc. depression / apathy, anxiety, sleep dysfunction).

Dr Little completed a masters degree in Experimental Psychology at Cambridge University, clinical medicine training at University College London and a PhD at the University of Oxford where he developed the first adaptive (closed-loop) deep brain stimulation algorithm for Parkinson’s disease. As a Clinical Lecturer at University College London, Dr Little investigated ultra-high spatial and temporal resolution human brain imaging, discovering rapidly dynamic brain oscillation bursts associated with movement during decision-making.

At UCSF since 2019 Dr Little has worked to advance brain recording and adaptive DBS using machine learning, resulting in the first demonstrations of at home symptom decoding and effective adaptive DBS using fully embedded DBS devices in both Parkinson’s disease and Dystonia. Additionally Dr Little has active projects understanding the neurocircuitry of mood, movement, anxiety and sleep with AI – towards the development of new precise and personalized neurostimulation therapies for motor and non – motor symptoms.


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