Known Neurophysiological Mechanisms and Phenomena: Foundations for Next-Generation DBS Therapies

Moderator(s)

• 

  Michael Moffitt, PhD

  Assoc. Professor or Biomedical Engineering
  Case Western Reserve University
  Cleveland, Ohio, United States

Co-Moderator(s)

• 

  Cameron McIntyre, PhD

  Professor
  Duke University
  Durham, North Carolina, United States

Speaker(s)

• 

  Dominique Durand, PhD

  Professor
  Case Western Reserve University
  Cleveland, Ohio, United States
• 

  Luis Lujan, PhD

  Associate Dean of Student Affairs; Associate Professor
  Mayo Clinic
  Rochester, Minnesota, United States
• 

  Shruti Nanivadekar, PhD

  MD-PhD Student
  Carnegie Mellon University
  Pittsburgh, Pennsylvania, United States
• 

  Luka Milosevic, PhD

  Assistant Professor & Scientist
  University of Toronto & University Health Network

Despite the success of DBS and SCS, their mechanisms remain unclear. This session explores known neurophysiological principles—excitability reduction, connectivity modulation, and plasticity—as a foundation for next-gen DBS therapies. By integrating mechanistic understanding with empirical insights, we aim to refine and advance neuromodulation strategies for improved clinical outcomes.